Adderall-page2

Drug Interactions-continued

Antidepressants- tricyclic

amphetamines may enhance the activity of tricyclic or sympathomimetic agents; d-amphetamine with desipramine or protriptyline and possibly other tricyclics cause striking and sustained increases in the concentration of d-amphetamine in the brain; cardiovascular effects can be potentiated.

MAO inhibitors

MAO antidepressants, as well as a metabolite of furazolidone, slow amphetamine metabolism. This slowing potentiates amphetamines, increasing their effect on the release of norepinephrine and other monoamines from adrenergic nerve endings, this can cause headaches and other signs of hypertensive crisis. A variety of neurological toxic effects and malignant hyperpyrexia can occur, sometimes with fatal results.

Antihistamines

Amphetamines may counteract the sedative effect of antihistamines

Antihypertensives

Amphetamines may antagonize the hypertensive effects of antihypertensives.

Chlorpromazine

Chlorpromazine blocks dopamine and norepinephrine receptors, thus inhibiting the central stimulant effects of amphetamines, and can be used to treat amphetamine poisoning

Ethosuximide

Amphetamines may delay intestinal absorption of ethosuximide

Haloperidol

Haloperidol blocks dopamine receptors, this inhibiting the central stimulant effects of amphetamines

Lithium carbonate

The anorectic and stimulatory effects of amphetamines may be inhibited by lithium carbonate.

Meperidine

Amphetamines pone the analgesic effect of meperindine

Methemamine therapy

Urinary excretion of amphetamines is increased, and efficiency is reduced, by acidifying agents used in Methemamine therapy

Norepinephrine

Amphetamines enhance the adrenergic effect of norepinephrine

Phenobarbital

Amphetamines may delay intestinal absorption of phenobarbital; co-administration of phenobarbital may produce a synergistic anticonvulsant action

Phenytoin

Amphetamines may delay intestinal absorption of phenytoin; co-administration of phenytoin may produce a synergistic anticonvulsant action

Propoxyphene

In cases of propoxyphene overdose, amphetamine CNS stimulation is potentiated and fatal convulsions can occur

Veratrum alkaloids

Amphetamines inhibit the hypotensive effect of Veratrum alkaloids

Drug/Laboratory Test Interaction

Amphetamines can cause a significant elevation in plasma corticosteriod levels. This increase is greatest in the evening. amphetamines may interfere with urinary steroid determinations.

Warnings

Clinical experience suggests that in psychotic children, administration of amphetamines may exacerbate symptoms of behavior disturbance and thought disorder. Data is inadequate to determine whether chronic administration of amphetamines may be associated with growth inhibition; therefore, growth should be monitored during treatment.

Usage in Nursing Mothers: Amphetamines are excreted in human milk. Mothers taking amphetamines should be advised to refrain from nursing.

Precautions

General Caution is to be exercised in prescribing amphetamines for patients with even mild hypertension. The last amount feasible should be prescribed or dispensed at one time in order to minimize the possibility of over dosage.

Information for Patients

Amphetamines may impair the ability of the patient to engage in potentially hazardous activities such as operating machinery or vehicles; the patient should therefore be cautioned accordingly.