Adderall
Adderall (Amphetamine Mixed
Salts):Indications
Attention Deficit Disorder with Hyperactivity: Adderall is
indicated as an integral proof of a total treatment program which typically
includes other remedial measures (psychological, educational, social) for a
stabilizing effect in children with behavioral syndrome characterized by
the following group at developmentally inappropriate symptoms:
- moderate to severe distractibility
- short attention span
- hyperactivity
- emotional lability
- impulsivity
The diagnosis of this syndrome should not be made with finality when
these symptoms are only of comparatively recent origin. Nonlocalizing
(soft) neurological signs, learning disability and abnormal EEG may or may
not be present, and a diagnosis of central nervous system dysfunction may
or may not be warranted.
Dosage and Administration
Regardless of indication, amphetamines should be administered at
the lowest effective dosage and dosage should be individually adjusted.
Late evening doses should be avoided because of the resulting
insomnia.
ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY
Not recommended for children under 3 years of age... In children from :
- 3-5 years of age, start with 2.5 mg daily; daily dosage may be raised
in increments of 2.5 mg at weekly intervals until optimal response is
obtained.
- 6 years and older, start with 5 mg once or twice daily; daily dosage
may be raised in increments of 5 mg at weekly intervals until optimal
response is obtained. Only in rare cases will it be necessary to exceed a
total of 40 mg per day. Give first dose on awakening; additional doses (1
or 2) at intervals of 4 to 6 hours. Where possible, drug administration
should be interrupted occasionally to determine if there is a recurrence of
behavioral symptoms sufficient to require continued therapy.
How Supplied
- 5 mg: Blue double scored tablet, debossed "AD" on one side and "5" on
the other side (NDC 58521-031-01)
- 10 mg: Blue double scored tablet, debossed "AD" on one side and "10" on
the other side (NDC 58521-032-01)
- 20 mg: Orange double scored tablet, debossed “AD” on one side and "20"
on the other side (NDC 58521-033-01)
- 30 mg: Orange double scored tablet, debossed "AD" on one side and "30"
on the other side (NDC 58521-034-01)
Store at room temperature.
Adderall (Amphetamine Mixed Salts):Possible Side
Effects and Warnings
Common Side Effects (usually wear off with time):
- Restlessness, dizziness, insomnia, headache, dryness of the mouth,
weight loss
Less Common Side Effects:
- Euphoria, unpleasant taste, diarrhea, constipation, other
gastrointestinal disturbances.
Contact a doctor if any of the following occur:
- Palpitations, tachycardia, elevation of blood pressure, psychotic
episodes at recommended doses (rare), over stimulation, dyskinesia,
dysphoria,
tremor, exacerbation of motor and phonetics and Tourette's syndrome.
Drug Interactions
- Acidifying agents - Gastrointestinal acidifying agents
(guanethidine, reserpine, glutamic acid HC1, ascorbic acid, fruit juices,
etc.)
- lower absorption of amphetamines
- Urinary acidifying agents - (ammonium chloride, sodium acid
phosphate, etc.)
- increase the concentration of the ionized species of the amphetamine.
- Primary excretion
- both groups of agents lower blood levels and efficiency of
amphetamines.
- Adrenergic blockers
- adrenergic blockers are inhibited by amphetamines.
- Alkalinizing agents - gastrointestinal alkalinizing agents (sodium
bicarbonate, etc.)
- increase absorption of amphetamines.
- Urinal alkalinizing agents (acetazolamide, some thiazides)
- increase the concentration of the non-ionized species of the
amphetamine molecule, thereby decreasing urinary excretion. Both groups of
agents increase blood levels and therefore potentate the actions of
amphetamines.
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